Scale Up and Bioprocessing

Strategies for optimization of bioprocesses for scale-up applications will be explored. In addition to the theory of scaling up unit operations in bioprocessing, students will scale up a bench-scale bioprocess (3 liters), including fermenta- tion and downstream processing to 33 liters. Specific topics include the effects of scaling up on: mass transfer and bioreactor design, harvesting techniques including tangential flow filtration and centrifugation, and chromatography (open column and HPLC).