The alternative
protein ecosystem

Francesco Manetti

Researcher

My lab focuses on advanced label-free microscopy and spectroscopy techniques for biomedical applications, but we would be keen to enter the field of alternative proteins. We use both spontaneous Raman and coherent Raman spectroscopy, which has 3D sectioning capabilities up to hundreds of microns in tissues and can be seamlessly coupled with TPEF and SHG microscopy in a multimodal fashion. Together, these techniques allow us to obtain detailed chemical, metabolic and structural information in a fast, label-free, and non-invasive way.  To give you an idea of the potentiality of our system for cultivated meat research, please consider this recent article from Shulamit Levenberg https://www.nature.com/articles/s42003-022-03852-5  With our optical setup, we could perform all the microscopy measurements presented in the study without the use of staining or markers, both at the single cell and at the tissue level, and provide even quantitative information about lipids and protein concentration, metabolic assessments and more. We are keen on entering the field and we are looking for academic collaborators or industry partners to start a joint research collaboration.

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