We unified several scientific and technological competences for the development of industrially viable L-Asparaginase production processes. We developed of new recombinant strains of bacteria and yeast with the capacity to produce L-asparaginases with longer half-life, greater stability, lower toxicity, and lower side effects in comparison to the biopharmaceutical currently in clinical use in Brazil and world. The project aims to develop a production process from optimization of microbial cultures to purification, pegylation and final formulation (lyophilized product), in sufficient quantity to carry out subsequent preclinical studies. The entire study will be accompanied by technical and economic evaluations (Quality by Design).
The alternative
protein ecosystem
Adalberto Pessoa-Junior
Researcher- Host institution: University of São Paulo
- Position: Principal investigator
- Discipline: Biochemistry, Bioengineering
- Alternative protein type: Fermentation
- Collaboration opportunities: Industry partnership, Joint research, Sharing equipment or facilities
- Hiring for: Graduate students, Postdoctoral fellows, Research staff, Undergraduate students
- Lab equipment: Biochemistry equipment (purification/separation/HPLC/GC/MS), Microbiology equipment, Standard molecular biology lab equipment (DNA/RNA/proteins/cells)
- Region: Latin America
- Technology focus: Bioprocess design, End product formulation and manufacturing, Ingredient optimization
- Location: São Paulo, Brazil